A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse
نویسندگان
چکیده
منابع مشابه
A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse.
Gaucher mice, created by targeted disruption of the glucocerebrosidase gene, are totally deficient in glucocerebrosidase and have a rapidly deteriorating clinical course analogous to the most severely affected type 2 human patients. An ultrastructural study of tissues from these mice revealed glucocerebroside accumulation in bone marrow, liver, spleen, and brain. This glycolipid had a character...
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ژورنال
عنوان ژورنال: Molecular and Chemical Neuropathology
سال: 1995
ISSN: 1044-7393
DOI: 10.1007/bf02962142